Reverse pumped hydro storage 

Reverse pumped hydro storage 


It is weird and counterintuitive, but has been demonstrated as a success. In pumped hydro storage facilities, they pump water up to a natural or man-made water body, using cheap electricity. Then, when the demand for electricity peaks — such as in the evenings — they release the water, which turns the turbines as it gushes down. This is classic hydro-storage.

Can you imagine water put underground, for the same purpose. Texas-based start-up Quindet Energy wants to do exactly that. Its idea is to pump water down into impermeable rock formations and keep it under pressure. When released, the water flows up under the pressure. “It’s like pumped hydro, upside down,” says CEO Joe Zhou. 

The start-up describes its amazing idea in three simple sentences. 

When there is surplus electricity, it is used to pump water from a pond down a well and held under pressure. The well is closed, keeping the energy stored under pressure for as long as needed. When electricity is needed, the well is opened to let the pressurised water pass through a turbine to generate electricity, and return to the pond ready for the next cycle. 

Published on September 22, 2025



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Role of microbiota in sex-specific immunity outcomes

Role of microbiota in sex-specific immunity outcomes


The study conducted by Ashoka University and IISER, Manauli, Punjab
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Men and women differ in their susceptibility to infections, autoimmune diseases, and responses to vaccines. However, the underlying mechanisms are not fully understood. Recently, the microbiota — the diverse community of microorganisms residing in animals — has emerged as a potential contributor to sex-specific immune outcomes.

A recent study conducted by Ashoka University and IISER, Manauli, Punjab – titled ‘Exploring the role of microbiota in mediating sexually dimorphic infection outcomes in mealworm beetles’ – explored whether differences in the microbiota between males and females could contribute to sexually-dimorphic responses to infection, and whether manipulating the microbiota could alter those outcomes. 

This, though, is not the first time a study examined the influence of microbiota composition on immunity. However, the authors say that there is limited direct evidence showing that microbiota differences cause differences in pathogen susceptibility. But Ashoka University, IISER, Manauli, researchers stumbled upon an interesting factoid while working with the beetle Tenebrio molitor. The researchers–Srijan Seal, Devashish Kumar, Pavankumar Thunga, Pawan Khangar, Manish Gupta, Dipendra Nath Basu, Rhitoban Roychoudhury and the team leader, Imroze Khan–have observed notable differences in microbiota composition between the sexes, along with a surprising finding: females were more susceptible to a bacterial infection than males. “This prompted us to investigate whether the observed susceptibility was linked to the microbiota and whether modifying it could influence infection outcomes,” the researchers say. 

The question before the researchers was whether sex-specific differences in microbiota composition could be associated with differences in susceptibility to bacterial infection. “We also wanted to test whether altering the microbiota — by depleting it or reintroducing it — would change the degree of susceptibility in males and females,” the researchers say.  

Sex, a key factor

The answer was ‘yes’. Immune responses and infection outcomes are not solely driven by genetic or hormonal factors, but can also be shaped by the microbiota. Environmental influences, such as diet and microbial exposure, have a key role in regulating immunity. By showing that the microbiota has a negative impact on infection resistance in females, but not in males, the researchers revealed that the immune – microbiota relationship may be fundamentally different between the sexes.

“This research contributes to a broader understanding of host–microbe interactions and suggests that sex should be considered a key factor in studies of immunity, disease susceptibility, and even in the design of microbiota-targeted therapies,” they say. 

The results revealed significant sex-specific effects. Under normal conditions, males were more successful at surviving infection, exhibiting lower bacterial loads and better infection clearance than females. When the microbiota was depleted, female survival significantly improved, effectively narrowing the gap between sexes. In contrast, male survival remained unchanged after microbiota depletion. Notably, when microbiota-depleted females were recolonised by consuming faecal matter, their susceptibility to infection returned to baseline levels. These findings suggest that the microbiota plays a detrimental role in female infection outcomes, while having little to no effect on males. 

These findings suggest that the microbiota serves as a critical mediator of sex differences in human immune function, with implications for medicine, epidemiology, and public health. They challenge the view that immunity is governed solely by intrinsic genetic or physiological traits, highlighting the influence of microbial communities. The study opens new avenues for understanding the interplay between sex, microbiota, and immunity and emphasises the importance of considering sex as a biological variable in both experimental design and therapeutic development. 

However, the study also raises intriguing evolutionary questions. Why do females maintain a microbiota that appears to reduce their infection resistance? Could certain microbes provide other physiological advantages — such as aiding in reproduction or nutrient absorption — that outweigh the costs to immune defense? “These possibilities warrant further investigation,” the researchers say. 

Published on September 22, 2025



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Control ALT1 for antifungal strategy

Control ALT1 for antifungal strategy


The study, published in Cell Communication and Signaling, offers the first direct evidence that targeting ALT1, or related pathways, could become a new antifungal strategy. 
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Researchers at the Wadhwani School of Data Science and AI (WSAI), IIT Madras, and the ICMR–National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH) have unveiled a promising new way to fight Candida albicans, the fungus behind life-threatening systemic candidiasis. Severe cases of this infection kill up to 63 per cent of patients, and drug-resistant strains have made new therapies urgent.

The team, led by Prof. Karthik Raman of IIT Madras and Dr Susan Thomas of ICMR-NIRRCH, used an integrated, data-driven approach that combined large-scale computer modelling with laboratory tests. Instead of relying on slow trial-and-error screening, they digitally recreated the metabolism of both the human host and the fungus to see how the pathogen behaves inside the body.

This model revealed previously hidden metabolic weak spots, highlighting the role of arginine metabolism and identifying the enzyme ALT1 as a crucial “metabolic bottleneck”. When ALT1 was deleted, C. albicans lost much of its ability to infect, a finding confirmed in mouse experiments.

The study, published in Cell Communication and Signaling, offers the first direct evidence that targeting ALT1, or related pathways, could become a new antifungal strategy. The researchers are now working with clinical partners to validate these insights in patient samples and explore industry collaborations to turn them into real treatments.

By marrying advanced computation with experimental biology, the work showcases India’s growing strength in interdisciplinary health research and points toward faster, more precise antifungal drug discovery that could save countless lives worldwide. 

Published on September 22, 2025



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Aditya L-1: What has India learnt about the Sun in two years?

Aditya L-1: What has India learnt about the Sun in two years?


Aditya L-1, India’s eye in the sky to observe the Sun, turned two this month. What exactly have Indian scientists learnt about the centre of our solar system in the last couple of years? 

The launch carried with it few instruments to help observe the Sun at historically close quarters. Key among these are the Solar Ultraviolet Imaging Telescope (SUIT) and the Vision Emission Line Coronagraph (VELC) – both made in India.

The SUIT device takes pictures of the Sun in different ‘colours’ of ultraviolet light to study phenomena such as solar flares. In an article published in The Astrophysical Journal of Letters in February this year, co-author Soumya Roy notes that for the first time, we were able to capture detailed images of a powerful solar flare (called the X6.3) as it erupted on the Sun’s visible surface. The authors also published another letter following the observation of a plasma blob from another flare. 

These images were taken in specific ultraviolet ‘colours’.

Why is this significant? 

Seeing flares in these particular light bands helps scientists understand the different layers of the Sun’s atmosphere and how flares develop. Over time, amassing data from hundreds of thousands of flares enhances human understanding of flares and their impact on space weather as well as on instruments on Earth. 

Dr Roy, now post-doctoral research fellow at the Manipal Centre for Natural Sciences, and his team observed that the brightest moments of the flare in certain narrowband UV colours (NB01, NB03, NB04, NB08) happened at the same time as bursts of high-energy X-rays (hard X-rays) and when the plasma reached its hottest temperature. This, he says, tells us that the UV light is coming from superheated gas, which gets hot as energetic particles in the flare slow down and dump their energy. 

In the case of the gas blob, this is the first time such a plasma blob has been seen in this specific near-ultraviolet light. Analysed data showed that the gas blob was actually cooler and denser than the gas it was moving through.  

Dr Roy, who specalises in solar flares, was also part of the team that developed the SUIT device.

Scientists were also able to observe that the blob’s sudden burst of speed happened at the same time as quick bursts of high-energy X-rays and specific radio signals were emitted. This likely points to a process called ‘magnetic reconnection’ – where tangled magnetic field lines suddenly snap and reconnect, releasing huge amounts of energy. This could have been the cause for the blob’s acceleration. 

To give you an idea of the SUIT’s capability, it was able to follow this blob (at speeds over 1,500 km per second!) to a much greater height (about 1,78,000 km) above the Sun’s surface than previous observations in near-ultraviolet light. Such tracking helps scientists understand the full journey and behaviour of these ejections. 

While recording the flares, SUIT also observed a very bright, small spot, called a kernel, within a flare. This bright spot is a sign of intense, concentrated heat and energy release in that part of the flare.  

The SUIT device is designed in such a way that it captures most flares irrespective of which side of the Sun it appears. “Because SUIT has on-board intelligence that can detect when a flare is taking place and where, it prioritises to read that first. The algorithm works that way, without human intervention.” 

When recording the flare in February this year, SUIT also observed two bright kernels in the narrowband 2 and narrowband 5 which had never been observed before.  

“Those are possibly some new flare lines that we don’t know of, or some kind of nuclear emission mechanism that has never been observed before, specifically narrowband 2.” He is expecting some results after analysis of simulations to predict the kernel. 

Scientists like Dr Roy are also studying the energy release from these flares. Explains Dr Roy, “Solar flares are magnetic explosions. The Sun is a bowl of, or a sphere of, boiling plasma that is held together by its own gravity and the magnetic field. Magnetic field lines in the solar atmosphere often rearrange and that releases the energy that you see in solar flares.”  

And when this rearrangement – the explosion happens – it dumps a lot of energy into the surrounding medium that accelerates a lot of electrons and ions down towards the Sun’s surface.  

“The kinetic energy that moves away creates the coronal mass ejection which gets the energy from the explosion, but a part of that explosion energy is also injected towards the Earth.” 

This creates the hard X-ray and UV-like lights we see from the Sun.

“It’s definitely some emission line, some new flare lines. To understand these better, we have to do simulations of solar flares and then develop models to see what kind of lines actually can come into emission in those wavelength bands,” explains Dr Roy. That is something he and his research mates are working on currently. 

Ozone layer

The SUIT could also help provide data that would eventually throw more light on how the ozone layer works. This holds promise to address concerns around global warming. Dr Roy points to three broadband filters in the device that look at three UV channels, which influence the photochemistry in the Earth’s stratosphere, and specifically in the ozone layer. 

These three bands provide direct inputs for atmospheric modelling. Atmospheric scientists, who model the photochemistry of the upper stratosphere, use simulations to predict changes in the ozone density on the Earth’s surface. Earlier, there were no direct way to measure the Sun’s irradiation in these specific wavelengths. 

As to how SUIT can actually help solar science advance, Dr Roy says, “The goal for me as a solar scientist, in studying solar flares, is when we see a flare, if we can predict what kind of changes in the solar atmosphere you will see over the next three to five days, because that is usually how long it takes for the disturbance from the Sun to come to Earth.”

Observing the Sun from historically close quarters will help mankind find ways to quickly respond to how solar flares impact the functioning of our satellites or even power grids on the ground, or, to the effect of flares on space weather, points out Dr Roy. 

The other instrument on the spacecrat, the VELC, is designed to study the Sun’s outer atmosphere (the corona) by looking at specific “colours” of visible light. According to a paper by Jagdev Singh and others published earlier this year in the Solar Physics journal, “the VELC was able to offer direct proof of a phenomenon called ‘coronal dimming’.”  

During a coronal mass ejection, parts of the Sun’s corona actually got darker. This is a direct observation of how the corona reacts to these massive explosions. This type of observation is critical for understanding the origin of mass ejections, their nature, and how they are propagated. 

‘Sit and stare’ observations that the VELC has enabled the study of periodic oscillations in coronal structures, which help in investigating the existence of waves, flows, and the dynamics of the corona — a primary step towards understanding the ‘coronal heating problem’. 

The coronal heating problem has for long left scientists puzzled – the corona, which is the outermost layer of the Sun, is much hotter than the photosphere below it, and it is not clear why. Hopefully, observations from Aditya L-1 will help unravel this mystery, too. 

Published on September 22, 2025



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India invites Russian firms to invest in innovative space ventures: Envoy

India invites Russian firms to invest in innovative space ventures: Envoy


Ambassador of India to The Russian Federation Vinay Kumar

India has invited Russian companies to invest in innovative space ventures in the country and tap its vast market, Ambassador Vinay Kumar said on Tuesday.

“The Government of India has offered lucrative schemes to create a conducive atmosphere in the space industry,” Kumar said while addressing a function at the Indian Embassy here to mark the second National Space Day.

The event commemorated the deployment of the Pragyan Rover on the Moon aboard Chandrayaan-3 on August 23, 2023.

Recalling decades of space cooperation between New Delhi and Moscow, he cited the launch of India’s first satellite Aryabhata on a Soviet rocket in 1975, the voyage of Rakesh Sharma aboard the Soyuz T-11 spacecraft in 1984, and the ongoing collaboration on the Gaganyaan human space mission.

The event was attended by officials and experts from Russia’s space organisation Roscosmos, which is closely working with ISRO.

Kumar noted that while space emerged as an industry only a few decades ago, in Indian tradition it has been part of life since the Vedic period.

“Scholars like Aryabhata studied the movement of celestial bodies and their impact on human lives. Today, from communication to navigation, space has become part of our daily life in India,” he said.

Students of the Embassy-run Kendriya Vidyalaya and members of the Jawaharlal Nehru Cultural Centre presented space-themed cultural performances at the function.

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Published on August 28, 2025



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OpenAI, Anthropic team up for research on hallucinations, jailbreaking

OpenAI, Anthropic team up for research on hallucinations, jailbreaking


OpenAI and Anthropic, two of the biggest rivals in artificial intelligence, recently evaluated each others’ models in an effort to better understand issues that their own tests may have missed.

In posts on both companies’ blogs on Wednesday, OpenAI and Anthropic said that over the summer they ran evaluations for safety on the other company’s publicly available AI models. They also tested for any propensity to make up facts and misalignment, a term commonly used to refer to an AI model not doing what the people building it want it to do.

The companies are high-profile competitors — Anthropic was founded by former OpenAI employees — making the collaboration notable. OpenAI called the joint safety effort the “first major cross-lab exercise in safety and alignment testing,” adding that the group hoped it would provide a “valuable path to evaluate safety at an industry level.”

AI companies are under increasing pressure to focus on the safety of their products following a string of reports of harmful behaviour linked to heavy use of the models. Most recently, a lawsuit was filed against OpenAI earlier this week alleged a teenager died by suicide after using the chatbot as a coach.

The companies carried out the evaluations before OpenAI released its new flagship AI model, GPT-5, and Anthropic rolled out the latest update to its Claude Opus model, Opus 4.1, in early August

More stories like this are available on bloomberg.com

Published on August 28, 2025



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