Chiral Perovskite films for next-gen optoelectronics

Chiral Perovskite films for next-gen optoelectronics


Most existing chiral materials are organic and conduct electricity poorly
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Scientists at the Centre for Nano and Soft Matter Sciences (CeNS), Bengaluru, have discovered how to control the crystallisation of chiral perovskite films — materials that can be used to build advanced devices, like circularly polarised light (CPL) detectors, spintronic components, and photonic synapses.

Chirality — when a structure is not superimposable on its mirror image — is a property seen in everything from DNA to spiral galaxies. In materials, it enables unique interactions with light and electrons, such as detecting circularly polarised light or controlling electron spin. These effects are key to emerging technologies in quantum computing, sensing, and optoelectronics. 

Most existing chiral materials are organic and conduct electricity poorly. Halide perovskites, however, excel at charge transport and possess tunable properties. By combining chiral molecules with low-dimensional halide perovskites, scientists can create hybrid materials with improved performance — but controlling how these films crystallise has been a major challenge.

The CeNS team studied thin films of methylbenzylammonium copper bromide ((R/S-MBA)₂CuBr₄) and found that crystal growth begins at the air-film interface and moves toward the substrate. Impurities form when solvent gets trapped during cooling, but careful solvent choice and vacuum processing can suppress these defects.

This insight offers a practical recipe for producing phase-pure, oriented chiral perovskite films, paving the way for efficient and scalable CPL detectors and other quantum optoelectronic devices. With India’s expanding semiconductor research base, such advances could help place the country in the vanguard of next-generation light-based technologies. 

Published on October 6, 2025



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Durable and powerful batteries

Durable and powerful batteries


Aluminum is efficient at storing and releasing energy but difficult to use because of complex chemistry. 
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Scientists in Bengaluru have created a breakthrough battery that’s flexible enough to fold like paper and safe to touch, offering a promising alternative to lithium-ion batteries used in phones, laptops, electric vehicles, and wearables. 

Lithium-ion cells can overheat and even explode. The new design, developed at the Centre for Nano and Soft Matter Sciences (CeNS) with the Centre for Nano Science and Engineering (CeNSE), IISc, replaces lithium with aluminum — one of Earth’s most abundant, eco-friendly metals — combined with a water-based electrolyte. This makes the battery safer, cheaper, and more sustainable. 

Aluminum is efficient at storing and releasing energy but difficult to use because of complex chemistry. The team overcame this by engineering materials at the microscopic scale. They built a cathode of copper hexacyanoferrate pre-filled with aluminum ions and paired it with a molybdenum trioxide anode. The result is a battery that maintains 96.8 per cent of its capacity after 150 charge–discharge cycles and bends or folds without losing power. 

To demonstrate, researchers powered an LCD display while folding the battery in half. Such flexibility could enable roll-up gadgets and clothing-integrated wearables, while its safety profile suits electric vehicles and other high-demand uses. 

Advanced electron-microscopy and spectroscopic tests confirmed the battery’s durability and high performance. By using abundant aluminum and a water-based system, the innovation supports global sustainability goals and positions India at the forefront of multivalent-ion battery research. With further refinement, this next-generation energy-storage technology could soon find its way into everyday devices and safer, greener transportation. 

Published on September 22, 2025



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When AI learns to look good…not necessarily be good

When AI learns to look good…not necessarily be good


A study found that models trained with FSRL dialled down features tied to honesty, safety, and ethics. 
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When companies talk about “aligning” AI with human preferences, the assumption is that the machines are being trained to be more honest, safe, and reliable. But new research suggests that alignment may be rewarding something else entirely: polish.

A paper titled The Anatomy of Alignment: Decomposing Preference Optimization by Steering Sparse Features (Ferrao et al., 2025) introduces a new alignment method called Feature Steering with Reinforcement Learning (FSRL). Beyond being a clever technical innovation, it reveals an awkward truth: when we reward AI, it learns to look good, not necessarily to be good.

Five takeaways

Alignment isn’t always about honesty. The researchers found that when models were trained with FSRL on human preference data, they systematically boosted features linked to style and formatting — punctuation, conciseness, neat structure — while dialling down features tied to honesty, safety, and ethics.

“The policy systematically increases the proportional activation of features related to style and formatting, while decreasing that of features explicitly tied to alignment concepts,” the authors note.

For businesses, this is a reminder that alignment can produce assistants that sound sharp and professional but may not always be more truthful.

Transparent methods are emerging. Traditional alignment through RLHF adjusts millions of parameters in opaque ways. Nobody can tell which switches are being pulled.

FSRL takes a more interpretable route. It uses Sparse Autoencoders (SAEs) to break down a model’s internal activations into meaningful “features” — like flattery, caution, or formatting — and then trains a lightweight adapter to nudge those features up or down.

Think of it as a control panel instead of a black box. Businesses deploying AI at scale could benefit from that visibility: knowing whether the “verbosity dial” is being cranked too far is better than guessing why customers are getting long-winded answers.

Trade-offs are unavoidable. In benchmark tests, the researchers compared FSRL with traditional full fine-tuning using Simple Preference Optimisation (SimPO).

Fine-tuned models improved alignment scores but saw reasoning collapse; performance on math reasoning tasks dropped dramatically.

FSRL-steered models achieved more moderate improvements but preserved much more of the model’s reasoning ability.

For operations, this highlights a trade-off: go too far in fine-tuning for “aligned” behaviour, and you may hollow out critical skills. Lightweight steering methods might give businesses the middle ground they need.

Operational benefits are clear. FSRL isn’t just more transparent; it’s also cheaper and faster. Instead of retraining entire models, you train small adapters. This lowers compute costs and allows for domain-specific steering.

A financial services firm could emphasise caution, a law firm precision, and a retailer conciseness, without destabilising the model’s core reasoning capabilities. In practice, this means alignment can become a more customisable business tool, not a one-size-fits-all process.

For regulators and auditors, transparency is key. Traditional RLHF methods give little insight into how alignment is achieved. With FSRL, organisations can literally see whether features corresponding to “flattery” or “avoidance” are being systematically promoted.

That could make AI oversight more like crash tests in cars or stress tests in banks — visible, measurable, and comparable. But the research also highlights a cultural weakness: if human raters reward style as a proxy for substance, then models will optimise for appearances. Businesses must ensure that feedback data reflects the qualities they truly value — honesty, nuance, and safety — not just the ones that look good on the surface.

The bottom line

The Anatomy of Alignment is both a tool and a warning. The tool — FSRL — shows that AI alignment can be done more transparently and cheaply. The warning is that unless businesses demand richer signals of quality, AI will keep learning the same shallow lesson: presentation is everything.

For executives thinking about deploying AI, the message is clear: don’t just ask whether the model sounds aligned. Ask what’s being rewarded under the hood. Because looking good, as every business leader knows, is not the same as being good.

Published on September 22, 2025



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Reverse pumped hydro storage 

Reverse pumped hydro storage 


It is weird and counterintuitive, but has been demonstrated as a success. In pumped hydro storage facilities, they pump water up to a natural or man-made water body, using cheap electricity. Then, when the demand for electricity peaks — such as in the evenings — they release the water, which turns the turbines as it gushes down. This is classic hydro-storage.

Can you imagine water put underground, for the same purpose. Texas-based start-up Quindet Energy wants to do exactly that. Its idea is to pump water down into impermeable rock formations and keep it under pressure. When released, the water flows up under the pressure. “It’s like pumped hydro, upside down,” says CEO Joe Zhou. 

The start-up describes its amazing idea in three simple sentences. 

When there is surplus electricity, it is used to pump water from a pond down a well and held under pressure. The well is closed, keeping the energy stored under pressure for as long as needed. When electricity is needed, the well is opened to let the pressurised water pass through a turbine to generate electricity, and return to the pond ready for the next cycle. 

Published on September 22, 2025



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Role of microbiota in sex-specific immunity outcomes

Role of microbiota in sex-specific immunity outcomes


The study conducted by Ashoka University and IISER, Manauli, Punjab
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Men and women differ in their susceptibility to infections, autoimmune diseases, and responses to vaccines. However, the underlying mechanisms are not fully understood. Recently, the microbiota — the diverse community of microorganisms residing in animals — has emerged as a potential contributor to sex-specific immune outcomes.

A recent study conducted by Ashoka University and IISER, Manauli, Punjab – titled ‘Exploring the role of microbiota in mediating sexually dimorphic infection outcomes in mealworm beetles’ – explored whether differences in the microbiota between males and females could contribute to sexually-dimorphic responses to infection, and whether manipulating the microbiota could alter those outcomes. 

This, though, is not the first time a study examined the influence of microbiota composition on immunity. However, the authors say that there is limited direct evidence showing that microbiota differences cause differences in pathogen susceptibility. But Ashoka University, IISER, Manauli, researchers stumbled upon an interesting factoid while working with the beetle Tenebrio molitor. The researchers–Srijan Seal, Devashish Kumar, Pavankumar Thunga, Pawan Khangar, Manish Gupta, Dipendra Nath Basu, Rhitoban Roychoudhury and the team leader, Imroze Khan–have observed notable differences in microbiota composition between the sexes, along with a surprising finding: females were more susceptible to a bacterial infection than males. “This prompted us to investigate whether the observed susceptibility was linked to the microbiota and whether modifying it could influence infection outcomes,” the researchers say. 

The question before the researchers was whether sex-specific differences in microbiota composition could be associated with differences in susceptibility to bacterial infection. “We also wanted to test whether altering the microbiota — by depleting it or reintroducing it — would change the degree of susceptibility in males and females,” the researchers say.  

Sex, a key factor

The answer was ‘yes’. Immune responses and infection outcomes are not solely driven by genetic or hormonal factors, but can also be shaped by the microbiota. Environmental influences, such as diet and microbial exposure, have a key role in regulating immunity. By showing that the microbiota has a negative impact on infection resistance in females, but not in males, the researchers revealed that the immune – microbiota relationship may be fundamentally different between the sexes.

“This research contributes to a broader understanding of host–microbe interactions and suggests that sex should be considered a key factor in studies of immunity, disease susceptibility, and even in the design of microbiota-targeted therapies,” they say. 

The results revealed significant sex-specific effects. Under normal conditions, males were more successful at surviving infection, exhibiting lower bacterial loads and better infection clearance than females. When the microbiota was depleted, female survival significantly improved, effectively narrowing the gap between sexes. In contrast, male survival remained unchanged after microbiota depletion. Notably, when microbiota-depleted females were recolonised by consuming faecal matter, their susceptibility to infection returned to baseline levels. These findings suggest that the microbiota plays a detrimental role in female infection outcomes, while having little to no effect on males. 

These findings suggest that the microbiota serves as a critical mediator of sex differences in human immune function, with implications for medicine, epidemiology, and public health. They challenge the view that immunity is governed solely by intrinsic genetic or physiological traits, highlighting the influence of microbial communities. The study opens new avenues for understanding the interplay between sex, microbiota, and immunity and emphasises the importance of considering sex as a biological variable in both experimental design and therapeutic development. 

However, the study also raises intriguing evolutionary questions. Why do females maintain a microbiota that appears to reduce their infection resistance? Could certain microbes provide other physiological advantages — such as aiding in reproduction or nutrient absorption — that outweigh the costs to immune defense? “These possibilities warrant further investigation,” the researchers say. 

Published on September 22, 2025



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Control ALT1 for antifungal strategy

Control ALT1 for antifungal strategy


The study, published in Cell Communication and Signaling, offers the first direct evidence that targeting ALT1, or related pathways, could become a new antifungal strategy. 
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Researchers at the Wadhwani School of Data Science and AI (WSAI), IIT Madras, and the ICMR–National Institute for Research in Reproductive and Child Health (ICMR-NIRRCH) have unveiled a promising new way to fight Candida albicans, the fungus behind life-threatening systemic candidiasis. Severe cases of this infection kill up to 63 per cent of patients, and drug-resistant strains have made new therapies urgent.

The team, led by Prof. Karthik Raman of IIT Madras and Dr Susan Thomas of ICMR-NIRRCH, used an integrated, data-driven approach that combined large-scale computer modelling with laboratory tests. Instead of relying on slow trial-and-error screening, they digitally recreated the metabolism of both the human host and the fungus to see how the pathogen behaves inside the body.

This model revealed previously hidden metabolic weak spots, highlighting the role of arginine metabolism and identifying the enzyme ALT1 as a crucial “metabolic bottleneck”. When ALT1 was deleted, C. albicans lost much of its ability to infect, a finding confirmed in mouse experiments.

The study, published in Cell Communication and Signaling, offers the first direct evidence that targeting ALT1, or related pathways, could become a new antifungal strategy. The researchers are now working with clinical partners to validate these insights in patient samples and explore industry collaborations to turn them into real treatments.

By marrying advanced computation with experimental biology, the work showcases India’s growing strength in interdisciplinary health research and points toward faster, more precise antifungal drug discovery that could save countless lives worldwide. 

Published on September 22, 2025



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